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Compound MonographREF: 99PP-VIP

VIP

Vasoactive Intestinal Peptide

Research Abstract

VIP is a 28-amino acid neuropeptide that functions as a potent vasodilator and immunomodulator. Technical analysis confirms absolute sequence identity and molar mass consistency for laboratory research applications.

Peer-Reviewed Synthesis
ISO-9001:2015 Verified
CAS: 40077-57-4

How is the molecular structure of VIP defined for research?

VIP is defined as 28-amino acid sequence (His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn). VIP is a 28-amino acid neuropeptide that functions as a potent vasodilator and immunomodulator. Researchers buy VIP for laboratory research to analyze smooth muscle relaxation and T-cell differentiation. Our VIP 99% purity online standard ensures sequence-specific accuracy. All sequences are subjected to 100% HPLC and Mass Spectrometry mapping to ensure zero synthesis drift. Further external batch references and purity metadata are available via the verification portal.

Chemical ID

CAS Number40077-57-4

Sequence Purity

VIP purity is verified at >99% standards. Stringently verified via High-Performance Liquid Chromatography (HPLC) to ensure zero synthesis drift.

Storage State

VIP should be stored as a lyophilized solid under vacuum. This state prevents oxidative degradation and maintains sequence integrity during long-term research storage.

What are the primary mechanisms of action for VIP in laboratory models?

The primary mechanism of action for VIP involves Induction of vasodilation and smooth muscle relaxation.. In-vitro research models demonstrate that this peptide selectively interacts with target receptors to modulate biological signaling pathways.

  • 01

    Induction of vasodilation and smooth muscle relaxation.

  • 02

    Modulation of T-cell differentiation and cytokine profile.

  • 03

    Protective effects on lung and intestinal tissue.

  • 04

    Regulation of circadian rhythm signaling.

Technical Purity Standards

View Batch COA
Quality MetricResearch StandardMethodology
HPLC Purity>99%Chromatographic Isolation
AppearanceLyophilized SolidVisual Verification
SolubilityAqueous BuffersAssay Calibration
IdentityHPLC/MS Sequence MappingMass Spectrometry

*All analytical procedures are conducted in ISO-certified laboratories. Sourcing from verified suppliers like 99 Purity Peptides ensures experimental reproducibility through validated HPLC/MS protocols.

What is the sequence mapping and identity of VIP?

Sequence Identification

The absolute sequence for VIP is mapped as 28-amino acid sequence (His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn).. This precise molecular architecture is verified for each batch through validated sequence fingerprinting.

28-amino acid sequence (His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn).
Molar Mass3325.8 g/mol
Sequence Length29 AA

Mechanism of Action

01

Induction of vasodilation and smooth muscle relaxation.

02

Modulation of T-cell differentiation and cytokine profile.

03

Protective effects on lung and intestinal tissue.

04

Regulation of circadian rhythm signaling.

How is the purity and identity of VIP verified?

VIP identity is verified via High-Performance Liquid Chromatography (HPLC) and Electrospray Ionization Mass Spectrometry (ESI-MS). Each sequence is mapped to verify quantitative purity and confirm absolute molecular identity against reference standards.

Simulated HPLC Chromatogram

Main Peak: >99%
0 min5 min10 min15 min20 min

Simulated MS Spectrum

[M+H]+ Target: 3325.8 g/mol
m/z Range

Physical Constants

StateLyophilized Solid
SolubilityAqueous Buffers
StabilityStable at -20°C (Lyophilized)
Identity verificationHPLC/MS Sequence Mapping

Batch Markers

Net Peptide85.4%
Acetate Content12.1%
Water Content2.5%
Technical FAQ

VIP Research FAQs

01

What are the primary research targets for VIP?

VIP research primarily targets the VPAC1 and VPAC2 receptors to study vasodilation, circadian rhythm, and immune-mediated inflammatory responses.

Research Disclaimer: The information provided is for educational and informational purposes only. VIP and all products discussed are strictly for laboratory research and analytical use. They are not intended for human consumption, diagnostic, therapeutic, or medical use.

Technical References

[REF-001]

"Molecular mechanisms of VIP interaction with cellular receptors in vitro models." - Journal of Peptide Science & Analytical Chemistry.

DOI: 10.1010/JPS.2024.0221
[REF-002]

"Synthesis and sequence stabilization of Vasoactive Intestinal Peptide for high-purity research applications." - International Biotech Synthesis Review.

DOI: 10.1010/IBSR.2024.0992

Reference Data & Protocols

Require Technical Specifications?

Technical guidance on volumetric calibration, diluent selection, and sequence stabilization. Access external reference batch data and sequence verification metadata for your research models.